If there is one thing in AutoCAD we can't live without - it's object snaps! We choose our object snap settings based on what we're doing at any given time (ideally not needing to change the settings very often). While hanging with the fabulous Autodesk Product Support folks in Lake Oswego - Volker Cocco brought up his speedy means of switching to his favorite osnap settings without the tedium of going through the status bar.
Check out my Cadalyst Video for more details!
Setting OSMODE directly can be a very powerful tool in your AutoCAD arsenal!